Initiation of Noninvasive Ventilation in ALS Patients With Chronic Respiratory Insufficiency

Launched by TAMPERE UNIVERSITY · Feb 23, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at a treatment called noninvasive ventilation (NIV) for people with amyotrophic lateral sclerosis (ALS) who have trouble breathing. The researchers want to find out if starting NIV in a doctor's office (outpatient) is just as effective as starting it in a hospital (inpatient). They will also evaluate the costs associated with both methods. The goal is to see if outpatient treatment can help patients manage their breathing difficulties more easily and affordably.

To participate in this trial, individuals need to have a confirmed diagnosis of ALS and experience chronic breathing problems or weakness in the muscles that help with breathing. However, those with severe cognitive issues that prevent them from giving consent, or those who already need a tracheostomy (a surgical opening in the neck for breathing), cannot join. Participants will receive support as they start NIV and will be part of a study that aims to improve care for people with ALS.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ALS diagnosed by a neurology and
• • chronic respiratory insufficiency or significant respiratory muscle weakness caused by ALS
• Exclusion Criteria:
• • impaired cognition to give informed consent to participation
• • contraindication to NIV therapy
• • another severe disease with a prognosis of less than one year
• • ventilation via an artificial airway, tracheostomy