Effects of Antihypertensive Drug Treatment on Brain Blood Flow, Cognition, and Regulation of Nervous System in Older Adults with Hypertension.

Launched by UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER · Feb 23, 2024

Keywords

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Gender

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Eligibility criteria

• Inclusion Criteria:
• • Older men and women with mild-to-moderate essential hypertension (60-85 years, clinic systolic BP 130-159 and/or diastolic BP 80-109 mmHg)
• Exclusion Criteria:
• • Any evidence of cardiovascular or pulmonary disease by medical history or by physical examination
• • Severe hypertension (systolic BP ≥160 and/or diastolic BP ≥110 mmHg; for safety reasons) or secondary hypertension
• • Being on ≥3 antihypertensive agents
• • Chronic kidney disease (an estimated glomerular filtration rate \>45 mL/min) or renal failure
• • Diabetes mellitus (fasting glucose ≥126 mg/dL or 2-hour oral glucose tolerance test, glucose level ≥200 mg/dL) or other systemic illness
• • Any history of substance abuse (other than tobacco)
• • Current cigarette smokers
• • History of gouty arthritis
• • Taking hormonal replacement therapy
• • Endurance-trained athletes
• • Diagnosed Alzheimer's disease and related dementias