Oral Dexamethasone for Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy

Launched by MANSOURA UNIVERSITY · Feb 24, 2024

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ClinConnect Summary

This clinical trial is studying whether taking a medication called dexamethasone the night before surgery can help prevent nausea and vomiting after laparoscopic cholecystectomy, which is a minimally invasive surgery to remove the gallbladder. Postoperative nausea and vomiting (PONV) can be quite common after this type of surgery, and the researchers want to see if this treatment can make a difference for patients.

To participate in the trial, you need to be an adult over 18 years old and scheduled for elective laparoscopic cholecystectomy. However, there are some important factors that would exclude you, such as if you have taken steroids or anti-nausea medications in the week before surgery, are on chronic opioid pain medications, or have certain health conditions affecting your liver or kidneys. If you join the trial, you can expect to take the medication before your surgery and then be monitored for any nausea or vomiting afterward. This study is currently looking for participants, so if you're interested, speak with your doctor to see if you might qualify.

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Eligibility criteria

• Inclusion Criteria:
• • all consecutive adults (older than 18 years) with ASA physical status I-III undergoing elective laparoscopic cholecystectomy surgery.
• Exclusion Criteria:
• • steroids or antiemetics within 1 week of surgery
• • chronic opioid therapy
• • history of allergy to any of the study drug
• • serum creatinine \> 1.4 mg/dl
• • liver enzymes \> triple the normal limits
• • pregnancy
• • patient refusal
• • and psychiatric or neurologic diseases or socioeconomic status that would hinder the postoperative quality of recovery questionnaire
• • laparoscopic surgery is converted to open surgery after enrollment