Spatial Transcriptomics in Kidney Transplantation

Launched by WESTERN SYDNEY LOCAL HEALTH DISTRICT · Feb 24, 2024

Keywords

ClinConnect Summary

Primary outcomes: The correlation of kidney transplant rejection subtypes with transcriptomic, spatial and cell-type features

Secondary outcomes: Correlation of the refined biopsy scoring criteria and transcriptomics signatures with:

1. All cause graft loss
2. Death censored graft loss
3. Treatment resistant rejection
4. Delayed graft function (DGF)
5. Biopsy evidence of borderline rejection based on current Banff scoring system
6. Biopsy proven acute rejection - T-cell mediated (TCMR), antibody-mediated (ABMR), mixed
7. Chronic rejection - acute or inactive
8. Interstitial fibrosis score...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All participants included in the study must be age ≥ 18 years old at time of enrolment and
• • 1. able to provide informed consent (interpreter permitted) for enrolment
• • 2. consenting to longitudinal follow up (can withdraw post enrolment)
• • 3. consenting to provide samples for biobanking, including blood, urine, faecal and/or kidney biopsy tissue (collected prospectively, separate to routine care)
• Exclusion Criteria:
• • Patients will be excluded from the study if they are
• • 1. unable (or unwilling) to provide consent, or
• • 2. have life-expectancy less than 6-months, or
• • 3. have received a haematopoietic stem cell transplant in the past 5 years.