Nerve Transfer to Improve Function in High Level Tetraplegia
Launched by WASHINGTON UNIVERSITY SCHOOL OF MEDICINE · Feb 23, 2024
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial, titled "Nerve Transfer to Improve Function in High Level Tetraplegia," is studying whether nerve transfer surgeries can help patients with severe cervical spinal cord injuries (specifically those affecting the neck) regain better use of their arms and improve their overall quality of life. The researchers are looking for participants who are between 18 and 80 years old, have a complete spinal cord injury at the C1 to C4 level, and have not shown any natural improvement for at least six months.
Participants in the study will undergo standard surgeries to transfer nerves, as well as various tests and questionnaires before and after the operation to track their progress. They will also have regular follow-up appointments with their surgeon over the next few years and attend therapy sessions to aid in their recovery. This trial is currently recruiting and is open to all genders, providing a potential opportunity for individuals with specific spinal cord injury conditions to improve their arm function and overall well-being.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • 18-80 years of age
- • High cervical SCI (motor level C1-C4)
- • Motor complete SCI AIS grade A-B
- • Plateaued spontaneous recovery for at least 6 months of non-operative therapy
- • SCI greater than 6 months and fewer than 60 months since injury
- • At least MRC 4/5 donor strength
- • Mentally and physically willing and able to comply with evaluations
- Exclusion Criteria:
- • Active infection at the operative site or systemic infection
- • Any return or ongoing recovery of distal motor function
- • Significant joint contractures and/or limitations in passive range of motion in the arm
- • Mentally or physically compromised making it impossible to complete study activities
- • Immunologically suppressed
- • Currently undergoing long-term steroid therapy
- • Active malignancy
- • Pregnancy
About Washington University School Of Medicine
Washington University School of Medicine is a leading academic medical institution renowned for its commitment to advancing healthcare through innovative research, education, and patient care. With a strong emphasis on translating scientific discoveries into practical applications, the institution conducts a diverse array of clinical trials aimed at improving treatment outcomes and enhancing the understanding of various medical conditions. Its collaborative environment fosters partnerships between researchers, clinicians, and community stakeholders, ensuring that the trials not only contribute to scientific knowledge but also address the pressing health needs of diverse populations.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Ann Arbor, Michigan, United States
Philadelphia, Pennsylvania, United States
Baltimore, Maryland, United States
Stanford, California, United States
Salt Lake City, Utah, United States
Miami, Florida, United States
Saint Louis, Missouri, United States
Edmonton, Alberta, Canada
Houston, Texas, United States
Calgary, Alberta, Canada
Patients applied
Trial Officials
Wilson Z. Ray, MD
Principal Investigator
Washington University School of Medicine
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported