Efficacy of Olanzapine on Weight Gain in Advanced Gynecologic Cancer with Paclitaxel and Carboplatin: a Double Blind, Placebo-controlled Randomized Trial
Launched by DEPARTMENT OF MEDICAL SERVICES MINISTRY OF PUBLIC HEALTH OF THAILAND · Feb 23, 2024
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying how effective a medication called olanzapine is in helping women with advanced gynecologic cancer gain weight while they are receiving two types of chemotherapy: paclitaxel and carboplatin. The trial will compare the weight gain of patients taking olanzapine to those taking a placebo, which is a pill that looks like the medication but has no active ingredients. This research aims to find out if olanzapine can help manage weight changes that some patients experience during treatment.
To participate in this trial, women must have advanced stage gynecologic cancer and be currently undergoing treatment with paclitaxel and carboplatin. They also need to be in good overall health, meaning they should have normal blood counts and liver and kidney function. Additionally, participants should be able to speak Thai or have a Thai caregiver to help with communication. However, women who are pregnant, have certain infections, or have specific medical conditions like diabetes or a severe weight issue are not eligible. If someone decides to join, they can expect to be part of a study that aims to improve the quality of life for patients undergoing cancer treatment.
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • Advanced stage gynecologic cancer receiving Paclitaxel and carboplatin chemotherapy
- • ECOG 0-1
- • Normal CBC,Liver, renal function
- • Communication in Thai language or Thai caregiver
- • Inform consent
- Exclusion Criteria:
- • Pregnancy
- • Active infection
- • Bowel obstruction or history of bowel surgery
- • On dopamine receptor antagonists or psychiatric or anticonvulsant medication
- • Olanzapine allery
- • Abnormal function of liver and renal
- • Diabetic melitus or morbid obesity
- • patient can't selfcare
About Department Of Medical Services Ministry Of Public Health Of Thailand
The Department of Medical Services, under the Ministry of Public Health of Thailand, is dedicated to advancing healthcare through rigorous clinical research and innovative medical practices. As a key sponsor of clinical trials, the department aims to enhance public health outcomes by evaluating new treatments, improving healthcare delivery, and ensuring the safety and efficacy of medical interventions. With a commitment to ethical standards and scientific integrity, the department collaborates with various stakeholders to address critical health challenges and promote evidence-based practices within the Thai healthcare system.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Bangkok, , Thailand
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported