Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)

Launched by UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER · Mar 1, 2024

Keywords

ClinConnect Summary

The clinical trial titled "Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)" is an observational study aimed at better understanding Postural Orthostatic Tachycardia Syndrome (POTS). POTS is a condition that affects how your body controls blood flow and blood pressure when standing up, which can lead to symptoms like rapid heart rate, dizziness, and fatigue. This study will involve various tests to gather detailed information about the disorder and will include both patients with POTS and healthy control participants.

To be eligible for this study, participants with POTS must be at least 14 years old, able to provide consent, and meet specific criteria related to their heart rate and symptoms. Healthy control participants need to be women aged 18 to 30 who do not have any symptoms related to POTS. Those who join the study can expect to undergo several tests and evaluations, which will help researchers learn more about POTS and potentially improve diagnosis and treatment in the future. The study is currently recruiting participants, so it's a great opportunity for those who meet the criteria to contribute to important medical research.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • POTS Patients
• • Age ≥ 14 years, able to provide informed consent (assent with parental consent for age \< 18) and comply with procedures
• • Meets consensus criteria for POTS: (1) sustained increase in heart rate ≥ 30 bpm above supine baseline within 10 min of quiet standing or upright tilt (≥ 40 bpm in individuals 12 to 19 years of age) OR sustained upright HR (heart rate) \>120 bpm, (2) absence of orthostatic hypotension, (3) symptoms with standing that improve with sitting or lying down, (4) resting supine heart rate \< 100 bpm, (5) orthostatic symptoms present for at least 6 months
• • Stable oral medication regimen for at least 14 days
• • Non-POTS Control Patients
• • Healthy women, age 18 - 30 years, able to provide informed consent and comply with study procedures
• • Does NOT meet consensus criteria for postural tachycardia syndrome
• • No symptoms of orthostatic intolerance or dysautonomia. No history of other major medical disorder
• • Resting supine heart rate \< 100 bpm
• Exclusion Criteria:
• None of the following exclusion criteria:
• • Use of amphetamine-type stimulants, diuretics, selective norepinephrine reuptake inhibitor, anticholinergic medications (including tricyclic antidepressant medications), fludrocortisone, desmopressin in past 14 days
• • Use of other autonomic drugs (adrenergic agents, pyridostigmine, droxidopa, triptans, ivabradine) in past 48 hours
• • Currently receiving IVIG (Intravenous immunoglobulin), subcutaneous IgG (Immunoglobulin G), or any investigational medication (in past year)
• • Infusion of iv fluids in past 7 days
• • History or evidence of another condition explaining symptoms or orthostatic tachycardia (e.g. structural heart disease, CSF (Cerebrospinal fluid) hypovolemia, or severe traumatic brain injury)