the 95% Effective Dose of Ciprofol for Adjunctive Sedation Undergoing Knee Arthroplasty in Elderly People

Launched by SECOND HOSPITAL OF SHANXI MEDICAL UNIVERSITY · Feb 27, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating the right dose of a medication called ciprofol, which is used to help elderly patients relax during knee surgery with spinal anesthesia. The goal is to find the dose that effectively sedates 95% of patients while minimizing side effects. As people age, their bodies can react differently to medications, so this study focuses on understanding how much ciprofol is safe and effective for older adults undergoing this type of surgery.

To be eligible for this trial, participants should be at least 65 years old, have a body mass index (BMI) between 18 and 28, and be in good health (classified as ASA grade I to III). However, those with certain health conditions, such as severe heart or lung issues, allergies to related medications, or those who have taken sedatives recently, will not be able to participate. If enrolled, participants can expect to receive careful monitoring during their surgery to ensure their comfort and safety. This study is currently recruiting, and it aims to improve sedation practices for older patients undergoing knee surgery.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 65 years
• • ASA grade I\~III
• • BMI 18\~28 kg/m2
• Exclusion Criteria:
• • Contraindications to intrathecal anesthesia
• • Suffering from severe psychiatric or neurologic disorders or taking sedative drugs within the last 3 months
• • Difficult airway or having respiratory diseases such as upper airway obstruction
• • Severe cardiovascular system diseases
• • Severe hepatic or renal dysfunction
• • Allergy or contraindication to propofol and its drug-related components
• • Patient Prefusal