Towards Optimal Fertility, Fathering and Fatherhood studY

Launched by KK WOMEN'S AND CHILDREN'S HOSPITAL · Feb 27, 2024

Keywords

ClinConnect Summary

The "Towards Optimal Fertility, Fathering and Fatherhood study" is a clinical trial designed to understand how different male factors influence the chances of pregnancy. The study will look at both fertile couples (those who are currently pregnant) and subfertile couples (those who have been trying to conceive for at least a year without success) to identify what aspects of male health and semen characteristics are linked to pregnancy outcomes. By combining information from both partners, the researchers hope to create a new measure that can help predict the likelihood of getting pregnant.

To participate in this trial, men must be between the ages of 21 and 49 and have a partner aged 21 to 39. Subfertile couples should have been trying to conceive for at least 12 months, while fertile couples must have a confirmed pregnancy in their partner that's less than 16 weeks along. It's important to note that certain conditions, such as known infertility issues or irregular menstrual cycles, may disqualify couples from participating. If eligible, participants can expect to provide information about their health and undergo assessments related to fertility throughout the study. This research aims to improve understanding of male fertility and ultimately help couples achieve their dream of having children.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Subfertile couples:
• • men aged ≥21-49 years
• • men with a female partner aged 21-39 years
• • couples who are not able to conceive for at least 12 months
• • couples who are Singapore citizen or permanent resident
• Fertile couples:
• • men aged 21-49 years
• • men with a female partner aged 21-39 years
• • men with proven fertility defined as those female partners who are currently pregnant and with viable intrauterine pregnancy at gestational weeks of less or equal to 16 at the time of the study
• • couples with attempted time to conceive within 12 months to achieve this pregnancy or with unplanned pregnancy
• • couples who are Singapore citizen or permanent resident
• Exclusion Criteria:
• Subfertile couples:
• • male infertility of a known aetiology including azoospermia, retrograde ejaculation, genetic disorders, cancer treatment, or testes trauma
• • female infertility diagnosis as confirmed by diagnostic imaging or having severe endometriosis
• • female partners with irregular menstrual cycle \>35 days
• • couples with known chromosomal abnormalities
• Fertile couples:
• • couples who achieve pregnancy after oocyte or spermatozoa donation
• • couples with known chromosomal abnormalities
• • female partners with known uterine abnormalities