Pericardial Fluid Analysis in Recurrent Pericarditis

Launched by ASST FATEBENEFRATELLI SACCO · Mar 2, 2024

Keywords

ClinConnect Summary

Idiopathic recurrent pericarditis is a condition characterized by recurrent inflammation of the pericardial sac and sometimes another serosa, accompanied by systemic signs and symptoms. Differential diagnosis of this condition includes all forms of pericarditis secondary to other diseases such as infections, autoimmune and autoinflammatory diseases, malignancy and other conditions (post-actinic, post-traumatic, post-pericardiotomy or post-infarct pericarditis, or those associated with metabolic dysregulations such as uremia). Some patients have pericardial effusion without any signs of infl...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with acute idiopathic or post-cardiac injury pericarditis who require diagnostic or therapeutic pericardiocentesis (Interventional arm)
• • Subjects with non-inflammatory pericardial effusion who require diagnostic or therapeutic pericardiocentesis (First control arm)
• • Patients who undergo cardiac surgery that involves a pericardiotomy (Second control arm)
• Exclusion Criteria:
• • Pregnancy or breastfeeding
• • Ongoing infections, including active viral hepatitis or Coronavirus Disease 19 (COVID-19) positivity in the previous 21 days
• • Systemic inflammatory disorders not attributable to pericarditis, excluding inflammatory diseases in remission
• • Solid or haematological malignancies, ongoing or less than 6 months disease-free interval or anti-blastic chemotherapy (excluding the hormone therapy)
• • Immunosuppressive therapy for reasons other than pericarditis treatment.
• • Moderate-severe kidney failure (GFR \< 30 ml/min)
• • Moderate-severe liver failure (Child-Pug B or C), active hepatitis
• • Diabetes mellitus
• • Severe hypoproteinemia/malnutrition