International Multicenter Project Comparing Radiofrequency Ablation Versus Implantable Defibrillator After Well-tolerated Ventricular Tachycardia in Ischemic Heart Disease with Minimally Impaired Ejection Fraction

Launched by UNIVERSITY HOSPITAL, TOULOUSE · Feb 27, 2024

Keywords

ClinConnect Summary

This clinical trial is exploring the best treatment option for patients with ischemic heart disease who experience a specific type of rapid heartbeat called ventricular tachycardia. The study is comparing two approaches: using a device called an implantable defibrillator, which can help prevent sudden heart problems, versus a procedure called radiofrequency ablation, which aims to destroy the heart tissue causing the abnormal heartbeat. Researchers want to find out which method is more effective and safer for patients who are stable and have a heart function that is still reasonably good.

To be eligible for this trial, participants should be between 65 and 74 years old, have a history of heart issues such as a heart attack, and have a specific type of ventricular tachycardia that does not cause fainting or heart failure. It’s important that they can provide informed consent and are part of a social security system. Throughout the study, participants will receive close monitoring and care while they undergo either treatment, helping doctors gather valuable information about the best way to help patients with similar heart conditions in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ischemic heart disease with history of infarction - LVEF\> 35% (measured by MRI)
• • sustained monomorphic ventricular tachycardia - without history of syncope or cardiac arrest -
• • having signed informed consent
• • affiliated to a social security system
• Exclusion Criteria:
• • transient regressive cause of ventricular tachycardia
• • recent myocardial infarction (\<2 months)
• • ventricular tachycardia by reentry from branch to branch
• • serious conduction disturbances (with indication of stimulation)
• • contraindication to the implantation of a defibrillator or to the performance of an ablation (life expectancy \<1 year, relevant comorbidities)
• • pregnancy
• • age \<18 years
• • Patient under legal protection, guardianship or curatorship