Evaluation of Free Gingival Graft Timing

Launched by UNIVERSITY OF ALABAMA AT BIRMINGHAM · Feb 28, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at two different ways to perform surgeries that help prepare the jawbone for dental implants. Specifically, it compares whether doing a free gingival graft (which involves taking tissue from the mouth to help with healing) before or after a procedure called guided bone regeneration (which helps build up the bone) leads to better results. The goal is to find out which order of these treatments is more effective for patients who need dental implants.

To be eligible for this study, participants should be at least 18 years old and in good health, meaning they don't have serious medical conditions or take medications that could hinder bone healing. They should also have missing teeth that need replacement and not have enough bone width in their jaw for the implants. Participants will undergo some evaluations before and after the surgery, and they will get support throughout the process. It’s important to note that individuals who smoke heavily, have certain health issues, or are pregnant or breastfeeding will not qualify for this trial.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • • At least 18 years old
• • No uncontrolled medical conditions or medications that will affect their bone healing.
• • Good oral hygiene is defined as a full-mouth plaque score ≤25%11.
• • Must be able to read and understand the informed consent document.
• • Has a need for implants to replace missing tooth/teeth in at least 1 quadrant of the mouth.
• • Insufficient alveolar ridge width for endosseous implant placement, defined as 5 mm or less, as determined by bone sounding and CBCT scan.
• • The patient and/or guardian is willing and able to comply with pre-operative and post-operative diagnostic and clinical evaluations required.
• • The patient is not pregnant or breastfeeding.
• Exclusion Criteria:
• • Active infectious diseases.
• • Liver or kidney dysfunction/failure.
• • Uncontrolled diabetes (HbA1c ≥ 8.5).
• • Active cancer treatment - such as active chemotherapy radiation therapy, or radiotherapy performed within ≤12 months from the procedure.
• • Taking medications that will affect their bone healing (for example, bisphosphonates and long-term anti-inflammatory medications).
• • Metabolic bone diseases that affect bone healing such as osteoporosis.
• • Pregnant or lactating women (self-reported).
• • Current tobacco and Marijuana smokers have 10 or more cigarettes per day, and former smokers (\> 10 cigarettes) who quit \< 10 ago (self-reported).
• • Poor oral hygiene.
• • Vertical loss of bone at the edentulous ridge.
• • History of periodontal disease.
• • The patient is pregnant or breastfeeding