Lung Cancer Screening by Artificial Intelligence Device

Launched by CHINESE UNIVERSITY OF HONG KONG · Feb 28, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how well an artificial intelligence (AI) device can help screen for lung cancer in non-smokers who have a close family member with a history of the disease. Currently, lung cancer screening is not recommended for non-smokers because there isn’t enough evidence to support it. However, this study aims to see if using AI to analyze low-dose CT scans can help find early signs of lung cancer in Asian non-smokers aged 50 to 75 who fit specific criteria.

To participate, individuals must be non-smokers (having smoked fewer than 100 cigarettes in their lifetime) and have a first-degree family member with lung cancer. Participants will undergo a low-dose CT scan and provide a blood sample. If any lung nodules are found, they will receive further tests and follow-up care. This trial is important because it hopes to improve lung cancer detection in a high-risk group while addressing challenges related to screening resources. If you meet the eligibility criteria and are interested, you may have the opportunity to contribute to this important research.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Patients are eligible to be included in the study only if all of the following criteria apply:
• • 1. Age 50-75 years old
• • 2. Non-smoker (defined as less than 100 cigarettes in lifetime)
• • 3. Having a first-degree family history of lung cancer
• • 4. Physically fit for curative treatment if early-staged lung cancer is found
• • 5. Able to provide written informed consent
• • 6. Consent to follow up visits and follow up CT scan if indicated
• • 7. Consent to blood taking for translational research
• Exclusion Criteria:
• Patients who meet any of the following exclusion criteria at screening are not eligible to be enrolled in this study:
• • 1. History of malignancy
• • 2. Smoking history (defined as more than 100 cigarettes in lifetime)
• • 3. Clinical symptoms suspicious for lung cancer e.g. haemoptysis, chest pain, weight loss
• • 4. Medical comorbidities that preclude curative treatment (surgery) for lung cancer, such as severe heart disease, acute or chronic respiratory failure, home oxygen therapy, bleeding disorder
• • 5. Pregnant ladies or ladies planning for conception
• • 6. History of tuberculosis or interstitial lung disease
• • 7. Pneumonia requiring antibiotic treatment within the last 12 weeks
• • 8. CT thorax or chest performed within 2 years (including LDCT or CT coronary angiogram)
• • 9. Unable or unwilling to provide written informed consent