Relative Contribution of Brain Insulin Action for Postprandial Metabolism

Launched by UNIVERSITY OF ULM · Mar 5, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how insulin, a hormone that helps control blood sugar levels, works in the brain and how it affects our body's metabolism after eating. Researchers want to understand if there are differences between men and women in how the brain regulates metabolism, especially considering the impact of the menstrual cycle in women. Participants will take part in tests that measure how their bodies handle sugar, using a method that involves taking a nasal spray with insulin on some days and a placebo (an inactive spray) on other days.

To join this study, participants should be between the ages of 65 and 75, have a Body Mass Index (BMI) of less than 24, and should not have any major health issues or be using hormonal birth control. Those with a history of drug or alcohol abuse, smoking, or certain health conditions that could affect safety or the study's success will not be eligible. If you choose to participate, you'll have the chance to contribute to important research that could improve our understanding of glucose metabolism and how it varies between individuals.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • BMI \< 24 kg/m2
• • no known primary diseases
• • no hormonal contraception
• Exclusion Criteria:
• • Alcohol or drug abuse
• • Smoking
• • At screening: Hb \< 12 g/dl for women and Hb \< 14 g/dl for men
• • Any (clinical) condition that would endanger participant's safety or question scientific success according to a physician's opinion.