Evaluating the Effect of Injectable Platelet-rich Fibrin on Accelerating Orthodontic Tooth Movement
Launched by HAMA UNIVERSITY · Mar 4, 2024
Trial Information
Current as of July 09, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying whether an injection of a substance called platelet-rich fibrin (PRF) can help speed up the movement of teeth during orthodontic treatment. The goal is to reduce the overall time patients spend in braces, making the treatment process quicker and more comfortable. Researchers are currently looking for participants who are between 18 and 26 years old, have specific types of misaligned teeth that may require the removal of a tooth, and have good oral health.
If you're interested in joining the trial, you should be aware that there are some health criteria. For example, you should not have any serious health conditions that could affect your teeth moving, and you shouldn’t have had prior orthodontic treatments. Participants can expect to receive the injectable treatment and will need to attend regular follow-up appointments to monitor their progress. This trial is an exciting opportunity to potentially improve orthodontic care for many patients!
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • The patient's age (18-26). Severe or very severe irregularity of the upper incisors greater than (7 mm) according to Little's index, so it is recommended to extract the upper first premolar.
- • Class I or Class II malocclusion, first model according to Angle, with skeletal class I or II and a normal or mild vertical growth pattern.
- • All permanent upper teeth, up to the first molar, are present, with the possibility of attaching brackets to all teeth in a correct position.
- • The patient has good oral health.
- Exclusion Criteria:
- • • The presence of any systemic disease that affects orthodontic dental movement.
- • Severe malalignment of one of the teeth (palatal quadrant, ectopic canine, ectopic premolar).
- • The patient has undergone previous orthodontic treatment.
- • The patient is subject to any drug treatment that may affect orthodontic dental movement (cortisone, non-steroidal anti-inflammatory drugs).
- • The patient has poor oral health.
- • Commitment to periodic follow-up appointments.
About Hama University
Hama University is a leading academic institution dedicated to advancing medical research and clinical trials aimed at improving healthcare outcomes. With a commitment to innovation and excellence, the university collaborates with multidisciplinary teams of researchers, clinicians, and industry partners to develop and evaluate novel therapies and treatment protocols. Hama University’s clinical trial efforts are characterized by rigorous scientific methodology, ethical standards, and a focus on patient-centered outcomes, positioning it as a pivotal contributor to the advancement of medical knowledge and the enhancement of community health.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Hama, , Syrian Arab Republic
Patients applied
Trial Officials
Eisa Salami, MSc student
Principal Investigator
Hama University
Rabab Alsabbagh, Professor
Study Chair
Hama University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported