Individualized Dosimetry for Holmium-166 Radioembolization in Patients With Unresectable Hepatocellular Carcinoma

Launched by IMPERIAL COLLEGE LONDON · Mar 4, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a treatment called QuiremSpheres®, which are tiny beads containing a radioactive substance, to see how safe and effective they are for patients with hepatocellular carcinoma (HCC), a type of liver cancer that cannot be surgically removed. The trial aims to find out how these microspheres affect the cancer and whether they cause any side effects. To join the trial, participants must be at least 18 years old, have a confirmed diagnosis of HCC, and have no other curative treatment options available. They should also be in relatively good health, with a life expectancy of at least six months.

If someone qualifies and decides to participate, they will first go through several tests, including imaging scans and blood tests, to ensure they are suitable for the treatment. Participants will receive a small initial dose of the microspheres to see how they spread in the body, followed by the full treatment if everything looks good. After treatment, there will be follow-up appointments to monitor their health and the effectiveness of the therapy. This trial is an important opportunity for patients seeking new ways to manage their liver cancer.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Provided written informed consent.
• • 2. Female or male aged 18 years and over.
• • 3. Diagnosis of HCC established according to AASLD criteria: nodule \>1 cm in a patient at risk for HCC, with combination of arterial hypervascularity and venous or delayed phase wash-out on multiphase CT-scan or MRI-scan. LR-5 and LR- 4 based on Liver Imaging Reporting and Data System can be included.
• • 4. No curative treatment options (resection, transplant, or in case of solitary tumour, RFA).
• • 5. Life expectancy of at least 6 months.
• • 6. ECOG Performance status 0-1.
• • 7. Liver-dominant disease (maximum 5 lung nodules all ≤1.0 cm, solitary clinically stable adrenal metastasis, and mesenteric or portal lymph nodes all ≤2.0 cm are accepted).
• • 8. Child-Pugh class A5-6 or B7.
• • 9. At least one measurable liver lesion according to the modified RECIST criteria.
• • 10. Negative pregnancy test for women of childbearing potential. Female patients of childbearing potential should use a highly effective acceptable method of contraception (oral contraceptives, barrier methods, approved contraceptive implant, long-term injectable contraception, intrauterine device or tubal ligation) or should be more than 1 year postmenopausal or surgically sterile during their participation in this study (from the time they sign the consent form), to prevent pregnancy.
• Exclusion Criteria:
• • 1. Evidence of significant extrahepatic disease (MRI-scan liver and multiphase abdominal CT as well as a thoracic CT are routinely performed at screening).
• • 2. Hepatic radiation therapy within the last 4 weeks before the start of study therapy.
• • 3. Previous or current treatment with RE. Previous treatment with TACE, surgery, RFA, and previous or current treatment with systemic treatment are allowed.
• • 4. Major surgery within 4 weeks or incompletely healed surgical incision before starting study therapy.
• • 5. Serum bilirubin \> 34 umol/L in the absence of a reversible cause
• • 6. Glomerular filtration rate \<35 ml/min.
• • 7. Non-correctable INR \>1.5 in case of femoral approach (as opposed to radial).
• • 8. Platelet count \<50 109/l.
• • 9. Significant cardiac event (e.g., myocardial infarction, superior vena cava (SVC) syndrome, New York Heart Association (NYHA) classification of heart disease ≥2) within 3 months before entry, or presence of cardiac disease that in the opinion of the investigator increases the risk of ventricular arrhythmia.
• • 10. Pregnancy or breastfeeding.
• • 11. Patients suffering from psychic disorders that make a comprehensive judgment impossible, such as psychosis, hallucinations and/or depression.
• • 12. Patients who are declared incapacitated.
• • 13. Previous enrolment in the present study.
• • 14. Male patients who are not surgically sterile or do not use an acceptable method of contraception during their participation in this study (from the time they sign the consent form), to prevent pregnancy in a partner.
• • 15. Evidence of untreated, clinically significant grade 3 portal hypertension (i.e. large varices at oesophagi-gastro-duodenoscopy). In these cases, therapy with non-selective beta-blocker (propranolol) or rubber band ligation should be instituted according to accepted guidelines. In case of small varices, prophylactic propranolol is advised.
• • 16. Portal vein thrombosis (tumour and/or bland) of the main branch (diagnosed on contrast enhanced transaxial images). Involvement of the right or left portal vein branches and more distal is accepted.
• • 17. Untreated active hepatitis. In case of detectable viral HBV load, appropriate treatment should be instituted.
• • 18. Transjugular intrahepatic portosystemic shunt (TIPS).
• • 19. Body weight over 150 kg (because of maximum table load).
• • 20. Severe allergy for intravenous contrast used (Visipaque®)
• • 21. Lung shunt \>30 Gy, as calculated using scout dose SPECT/CT.
• • 22. Extrahepatic deposition of scout dose activity. Activity in the falciform ligament, portal lymph nodes and gallbladder is accepted.