Post-surgical Outcomes With Anabolic Agent Use in High-risk Ankle Fractures: A Pilot RCT

Launched by UNIVERSITY OF CALGARY · Mar 4, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how a medication called Teriparatide, which helps build stronger bones, can improve recovery after ankle surgery in older adults who are at higher risk for complications. The study focuses on patients aged 60 and older who have low-energy ankle fractures, like those that happen from a simple fall, and who also have additional health issues such as osteoporosis, diabetes, or vascular disease. By giving some participants Teriparatide and others a placebo (a substance with no active ingredients), researchers hope to find out if the medication can help reduce complications, speed up healing, and improve overall outcomes after surgery.

If you or a loved one are considering participating, you would need to be over 60 years old and meet certain health criteria. Participants will receive either the study medication or the placebo for three months. Throughout the trial, researchers will monitor recovery, any complications, and the need for repeat surgeries. This study is an important first step that may lead to larger trials aimed at improving care and reducing the risks associated with ankle fractures in older adults.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Our study will include men and women over 60 years of age presenting to the emergency department with low energy ankle fractures (fall from standing height) requiring surgical treatment and who have one or more of the following risk factors, diabetes, osteoporosis, renal disease, steroid use, smoking history, peripheral neuropathy and/or vascular disease.
• Exclusion Criteria:
• • Individuals will be excluded if they have received previous Teriparatide therapy, or they have hypercalcemia or hyperparathyroidism, as these are precautions to the use of Teriparatide.