Predictive Model for the Occurrence of Cerebral Vasospasm Complicating Subarachnoid Haemorrhage by Combined Analysis of the Kinetics of a Panel of Biomarkers.

Launched by UNIVERSITY HOSPITAL, BORDEAUX · Mar 4, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a way to predict a condition called cerebral vasospasm, which can occur after a type of bleeding in the brain known as subarachnoid hemorrhage. The goal is to develop a model that uses both clinical information from patients and specific biological markers found in their blood to foresee if they might experience cerebral vasospasm within 14 days of their initial bleeding. This research is being conducted in an intensive care unit, where patients will be monitored closely for up to 14 days.

To be eligible for this trial, patients should have experienced subarachnoid hemorrhage less than four days prior to their admission and must provide consent for participation. The study includes both men and women, typically aged 65 and older. Participants can expect to have blood samples taken daily for up to ten days to analyze these biomarkers. It's important to note that the results of the blood tests and any indications of cerebral vasospasm will be kept separate to ensure unbiased results. This trial aims to improve the care and outcomes for patients recovering from this serious condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Subarachnoid hemorrhage (of aneurysmal or non-aneurysmal etiology) less than 4 days prior to admission to neuro-resuscitation, diagnosed on clinical presentation and confirmed by brain imaging.
• • Free, informed and written consent signed by the patient (or, failing this, his or her representative).
• • Patient entitled to or affiliated with social security
• Exclusion Criteria:
• • Significant vasospasm on admission to the department, diagnosed on initial imaging
• • Patient whose short-term survival (48 hours) appears compromised
• • Contraindication to perfusion CT scan
• • Pregnant or breast-feeding women
• • Patient under legal protection (persons deprived of liberty or under guardianship)