Application of FDG Combined With FAPI PET Dual Imaging in the Diagnosis and Staging of Oropharyngeal and Laryngeal Cancer

Launched by DAPING HOSPITAL AND THE RESEARCH INSTITUTE OF SURGERY OF THE THIRD MILITARY MEDICAL UNIVERSITY · Mar 5, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating a new imaging method for diagnosing and staging oropharyngeal (throat) and laryngeal (voice box) cancers. The goal is to see if a combination of two types of scans—FDG PET and FAPI PET—can provide more accurate information about how advanced the cancer is compared to traditional methods. This is important because accurate staging can help doctors decide the best treatment options and improve patient outcomes.

To participate in the trial, you need to be at least 18 years old and have a strong suspicion of having oropharyngeal or laryngeal cancer based on imaging tests. This includes people who have recently been diagnosed and are planning surgery, as well as those who have already started treatment and need further staging. However, if you have certain conditions, like refusing surgery or having other types of cancer, you may not be eligible. If you join the study, you can expect to undergo these advanced imaging tests, which are non-invasive and designed to give a clearer picture of the cancer’s status. Your participation could contribute to better methods for diagnosing and treating these types of cancer in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients with high clinical suspicion of oropharyngeal and laryngeal cancer: CT and MR examinations reveal space occupying lesions in the oropharynx and laryngopharynx, with high suspicion of laryngeal cancer;
• • 2. Recently diagnosed patients: patients who have recently been diagnosed with oropharyngeal cancer and laryngeal cancer, have not undergone surgical resection but are willing to undergo surgery;
• • 3. Patients who have been diagnosed with oropharyngeal and laryngeal cancer and have undergone concurrent radiotherapy, chemotherapy, or immunotherapy, and are preparing to undergo preoperative staging in the near future;
• • 4. Patients with high suspicion of oropharyngeal and laryngeal cancer through imaging examination, and later confirmed by pathology as non oropharyngeal or laryngeal cancer;
• • 5. Patient age ≥ 18 years old;
• • 6. The patient voluntarily participates and signs an informed consent form.
• Exclusion Criteria:
• • 1. Patients who refuse to undergo surgery;
• • 2. Patients highly suspected of lymphoma or metastasis in clinical or imaging studies;
• • 3. Patients with multiple neck metastases identified through imaging examination that cannot be surgically treated;
• • 4. Patients with malignant tumors in other parts of the body found through imaging examination that cannot be operated on;
• • 5. Pregnancy or lactation period;
• • 6. The imaging quality is poor and cannot be used for diagnosis and evaluation;
• • 7. Patients with contraindications for MR examination.