Comparison of Two PPOS Models for Pituitary Suppression

Launched by NEXTFERTILITY · Mar 4, 2024

Keywords

ClinConnect Summary

This clinical trial is designed to compare the effects of two different medications, known as progestogens, on women's fertility during egg donation programs. The goal is to see which progestogen works better in helping women produce healthy eggs, while also ensuring safety and efficiency. This is particularly important for women undergoing fertility treatments, especially in international egg donation and fertility preservation situations, where standardized methods can lead to better outcomes.

To be eligible for the trial, participants must be women aged 18 to 39 with a healthy body weight and a good number of follicles (small structures in the ovaries that contain eggs). They should not have any active sexually transmitted infections or use hormonal birth control for at least a month before starting the study. Participants can expect to take part in a process that evaluates how well the two medications perform in helping to retrieve eggs for donation. The trial is not yet recruiting participants, but it aims to provide valuable insights into improving fertility treatments for women.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • BMI of 18-29,9 kg/m2
• • Ultrasound count of antral follicles prior to COH ≥ 12 follicles
• • Meeting the criteria for inclusion in the egg donation program
• • Normal karyotype and no active sexually transmitted diseases
• • No use of combined hormonal contraceptives one month before COH
• Exclusion Criteria:
• • Patients excluded from the egg donation program
• • Untreated sexually transmitted diseases, positive serology for HBV, HIV, HCV
• • Blood disorders, neurodegenerative/psychiatric diseases, carriers of X-linked genetic diseases, oncological diseases, endometriosis.
• • Oligomenorrhea (\<1 menstrual cycle in 3 months)
• • Use of combined hormonal contraceptives before COH