A Study Assessing the Effects of Acupuncture in Parkinson's Disease Patients With Chronic Appendicitis

Launched by THE FIRST AFFILIATED HOSPITAL OF UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA · Mar 4, 2024

Keywords

ClinConnect Summary

This clinical trial is exploring the effects of acupuncture on patients with Parkinson's Disease (PD) who also have chronic appendicitis. Researchers believe that symptoms of Parkinson's, such as difficulty moving and constipation, may be linked to intestinal issues. By using acupuncture at specific points related to these problems, the study aims to see if participants experience improvements in their motor symptoms and overall quality of life. Acupuncture may also help with non-motor symptoms of Parkinson's, such as anxiety, sleep disorders, and cognitive difficulties.

To be eligible for the trial, participants must have certain movement symptoms of Parkinson's, confirmed chronic appendicitis, and be stable on their medications for at least two weeks. The trial is open to all genders and ages between 14 and 25. Those who have severe neurological disorders or other serious health issues may not be eligible. Participants can expect to receive acupuncture treatment and be part of assessments to see how effective this approach is in improving their symptoms.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients presenting with bradykinesia, combined with resting tremor and/or myotonia.
• • Appendix CT suggested chronic appendicitis evaluated by two experienced experts.
• • All subjects and their guardians give informed consent to the content of this study and sign informed consent.
• • Normal coagulation function.
• • If the patient had taken oral anti-PD drugs, it had been stable for at least 2 weeks at enrollment.
• Exclusion Criteria:
• • Treatment with dopamine blockers or dopamine depleters in doses and time courses consistent with drug-induced parkinsonism.
• • Neuroimaging examination of presynaptic dopaminergic system function was normal.
• • Patients who had suffered severe brain trauma or underwent complex craniotomy within 5 years prior to enrollment.
• • Cognitive disorders that are not on the Parkinson's spectrum, such as Alzheimer's disease, frontotemporal dementia, and Niemann-Pick disease, have been diagnosed.
• • People diagnosed with severe neuropsychiatric disorders (epilepsy, bipolar disorder, major depressive episode, etc.) according to DSM-V.
• • Complicated with serious systemic diseases, disorders of consciousness, stroke, serious coronary heart disease, diabetes, liver and kidney diseases, and serious visual and hearing disorders.
• • Patients with severe organic or functional dysphagia;Those who were deemed by the researcher to be unable to complete the visit and auxiliary examination as required by the study protocol.