Immediate Versus Postponed Single Blastocyst Transfer in Programmed or Stimulated Cycle Frozen Embryo Transfer

Launched by RIGSHOSPITALET, DENMARK · Mar 8, 2024

Keywords

ClinConnect Summary

This clinical trial is exploring the best timing for transferring a single blastocyst (a type of embryo) in women undergoing frozen embryo transfer (FET) after in vitro fertilization (IVF). Specifically, it compares transferring the embryo right after the egg retrieval (immediate transfer) with transferring it in a later cycle (postponed transfer). The main goal of the study is to find out if the immediate transfer results in a similar chance of a live birth as the postponed transfer.

To participate in this trial, women should be eligible for a frozen embryo transfer and have at least one good-quality blastocyst ready for transfer. This includes women with irregular menstrual cycles or those who have regular cycles. However, some women may not be eligible if they have certain uterine conditions or other specific health issues. Participants will have the chance to contribute to important research that could help improve fertility treatments for others in the future.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Eligible for FET in a programmed- or stimulated cycle immediately following a fresh embryo transfer or freeze all cycle
• • Oligo-anovulatory women (cycle length \> 35 days)
• • Ovulatory women (cycle length 21-35 days)
• • At least one vitrified day 5 or 6 blastocyst with Gardner score of ≥ 3BB at the day of vitrification
• Exclusion Criteria:
• • Uterine malformation
• • Presence of hydrosalpinx, submucosal uterine myomas or uterine polyps
• • Allergies or contraindication to standard fertility medication
• • Male or female HIV or Hepatitis B or C
• • Preimplantation genetic testing (PGT) in the fresh cycle
• • Testicular sperm aspiration (TESA)
• • Severe OHSS with hospital admission and ascites drainage during the fresh cycle
• • Oocyte donation