Protocol Optimization in CT for the Quantification of BMD

Launched by HATEM ALKADHI · Mar 7, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how well a new type of CT scan, called photon-counting CT, measures bone mineral density (BMD) compared to a traditional method known as DXA scanning. Bone mineral density is important for diagnosing conditions like osteoporosis and osteopenia, which are related to weak bones. The goal of the study is to see if the new CT scan can provide accurate measurements of BMD and to find ways to improve how these scans are done.

To participate in this trial, individuals must be between the ages of 65 and 74 and have a doctor's referral for a CT scan that includes the lower back area. Participants will need to give their consent and may require an interpreter if they speak a different language. If chosen for the study, they will have a CT scan on the same day as their regular appointment and a separate appointment for the DXA scan. It’s important to know that certain conditions, such as being pregnant or having specific medical issues, may prevent someone from participating. Overall, this trial aims to improve the way we measure bone health to better help patients at risk of fractures.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Informed Consent signed by the subject
• • Referral to a regular clinically indicated CT examination covering the lumbar area (e.g., Abdomen, Thorax + Abdomen, Neck + Thorax +Abdomen)
• • Informed written and oral consent (interpreter present in case of foreign language patients)
• • No contraindication to the clinically indicated CT examination
• Exclusion Criteria:
• • Patients \< 18 years
• • Pregnant women
• • Vulnerable subjects
• • Contraindications to the clinically indicated CT scan
• • Multiple Myeloma
• • Diffuse bone metastasis
• • Fixateur interne in the lumbar spine
• • Kyphoplasty in the lumbar spine
• • Enterally administrated contrast agent
• • Obtaining informed consent is not possible
• • Withdrawal of consent orally or in writing
• • Inability to follow the procedures of the investigation, e.g., due to language problems, psychological disorders, dementia, etc. of the subject
• • Immobility (patients confined to a wheelchair or to bed)