Efficacy and Safety of Tranilast Combined With Minocycline in the Treatment of Rosacea

Launched by SECOND AFFILIATED HOSPITAL OF XI'AN JIAOTONG UNIVERSITY · Mar 8, 2024

Keywords

ClinConnect Summary

Rosacea is a chronic inflammatory skin disease with a complex pathogenesis involving multiple factors. Currently, the treatment of rosacea remains highly challenging. In the skin, mast cells are located in the dermis near nerve endings and blood vessels, playing a crucial role in inflammatory responses. Mast cells, as key participants in the pathogenesis of rosacea, have been shown to alleviate rosacea symptoms with some topical, oral, and injectable mast cell stabilizers in recent years. Tranilast stabilizes mast cells and basophils by acting on their cell membranes and preventing their de...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Males and nonpregnant females, aged 18-60 years old;
• • 2. Diagnosed with erythematotelangiectatic or papulopustular rosacea, with an investigator' s global assessment of 3-5;
• • 3. Patients with good cognitive function and normal mental status;
• • 4. Patients with good communication skills;
• • 5. Voluntary participation in the study and signing of informed consent form.
• Exclusion Criteria:
• • 1. Allergy to any component of tranilast capsules;
• • 2. Allergy to any component of minocycline capsules;
• • 3. History of systemic medication for rosacea treatment within the past month;
• • 4. Pregnancy or lactation;
• • 5. Presence of severe primary diseases in addition to rosacea, such as cardiovascular system, cerebrovascular system, digestive system, urinary system, hematopoietic system diseases, or systemic failure.