Intra-Hepatic Microbiota in Alcoholic Hepatitis

Launched by HOSPICES CIVILS DE LYON · Mar 6, 2024

Keywords

ClinConnect Summary

This clinical trial is focusing on understanding the role of bacteria in the liver of patients suffering from alcoholic hepatitis (AH), a serious condition related to alcoholic liver disease. Researchers want to learn how the bacteria in the liver, blood, and gut might affect the severity of AH and patient outcomes. They will study 50 patients who have been diagnosed with alcoholic liver disease and show signs of AH. By analyzing the types of bacteria present, they hope to find new ways to treat this condition, especially since current treatments only work for some patients.

To be eligible for this study, participants must be at least 18 years old and have alcoholic liver disease with signs of AH, such as jaundice and heavy alcohol use. They should also be scheduled for a specific kind of liver biopsy. However, those who have recently taken antibiotics or probiotics, are pregnant, or have certain medical conditions may not be able to participate. If you join the study, you can expect to have a liver biopsy and provide samples for analysis, helping researchers gather important information that could lead to better treatments for AH in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients suffering from alcoholic liver disease and clinical suspicion of alcoholic hepatitis (subacute jaundice, heavy alcohol consumption active or weaned for ≤ 3 months, modified Maddrey score ≥32) and indication for diagnostic transjugular liver biopsy;
• • Non-objection obtained from the patient or trusted person in case of impaired judgment or consciousness before performing liver biopsy;
• • Aged ≥ 18 years at the time of study entry;
• Exclusion Criteria:
• • Patients who have been treated with antibiotics or probiotics within the last 15 days prior to liver biopsy, with the exception of antibiotics used for prophylaxis of ascites infection or hepatic encephalopathy
• • Contraindication to transjugular liver biopsy (hepatocellular carcinoma on predicted puncture site)
• • Pregnant, parturient or breast-feeding women
• • Persons deprived of their liberty by judicial or administrative decision
• • Adults under legal protection (guardianship, curators)