Prehabilitation With Resistance-exercise Training for Breast Cancer Neoadjuvant Therapy

Launched by UNIVERSIDAD DE LA FRONTERA · Mar 6, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating a program called prehabilitation, which includes resistance-exercise training for women with breast cancer who are about to start chemotherapy before surgery. The goal is to see if this type of exercise can help improve muscle strength and overall health during treatment. Many women experience fatigue and loss of muscle mass during cancer treatment, which can affect their recovery and quality of life. By starting resistance exercises early, researchers hope to help patients maintain their strength and better endure the challenges of chemotherapy.

To participate in this study, women must be postmenopausal and diagnosed with certain types of breast cancer, including stages I, II, and III. They should also be planning to receive chemotherapy before surgery and have a body mass index (BMI) between 18.5 and 30. Participants should not be exercising regularly and must be willing to follow the exercise program outlined in the study. It's important to note that women with certain health conditions or previous cancer treatments may not be eligible. If you join the trial, you'll be part of an effort to improve treatment outcomes for breast cancer patients while also receiving support to enhance your physical health during this critical time.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Postmenopausal women with breast cancer in stages I, II and III with luminal breast tumor, HER2+ or TNBC
• • Indication for neoadjuvant chemotherapy
• • Candidates for curative breast surgery
• • Body mass index: 18.5 \<BMI \<30 kg/m2
• • Sedentary (does not perform scheduled or planned physical activity ≥ 2 times a week)
• • Willingness to participate in the study and follow the proposed prehabilitation scheme.
• Exclusion Criteria:
• • Present comorbidities that interact with the metabolism and mobility of the muscles of the body and that do not allow the (safe) performance of strength exercises (e.g., debilitating arthritis, all neurological disorders, paralysis, among others).
• • Severe or uncontrolled cardiovascular disease, cardiac ejection fraction less than 50%
• • Previous antineoplastic treatment
• • Use of nutritional supplements (leucine, glutamine, casein, whey protein, fatty acids and creatine).