Mechanical Insufflation-exsufflation and Hypertonic Saline in Nosocomial Bacterial Respiratory Tract Infection

Launched by HOSPITAL SAN CARLOS, MADRID · Mar 12, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a combination of two treatments—mechanical insufflation-exsufflation (IEM) and hypertonic saline (HS)—for patients who have developed lung infections while in the hospital, especially those who are on artificial ventilation in the intensive care unit (ICU). The goal is to find out if clearing out infected mucus through suctioning (aspiration) and using nebulized hypertonic saline can help patients recover from these serious lung infections more effectively than just using antibiotics alone.

To participate in this trial, patients must be between 65 and 74 years old and have a specific type of lung infection known as nosocomial pneumonia or tracheobronchitis, and they must be intubated (having a breathing tube). Participants will be asked to sign a consent form, and they will receive either the new treatment combination or standard care. It’s important to note that certain patients with severe health issues, such as those with unstable conditions or significant lung complications, will not be eligible for the study. This research is still in the planning stages and has not started recruiting participants yet.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Signed informed consent
• • Nosocomial pneumonia (vHAP or VAP) or nosocomial tracheobronchitis
• • Intubated with a cuffed endotracheal tube or tracheostomy cannula.
• Exclusion Criteria:
• • Ominous prognosis
• • Frank hemoptisis
• • Barotrauma (pneumothorax or pneumomediastinum)
• • Bronchospasm (patients on bronchodilators for previous bronchospasm may be included
• • Unstable thoracic cage
• • Suspected unmonitored intracraneal hypertension