Evaluating Use of Topical Imipramine and Amitriptyline in Reducing Ultraviolet B Light-Induced Redness in Patients With Rosacea

Launched by WRIGHT STATE UNIVERSITY · Mar 8, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of two topical medications, imipramine and amitriptyline, on reducing redness caused by sunlight in patients with rosacea. Rosacea is a skin condition that leads to a red face and can cause discomfort, especially when exposed to UV light from the sun. The researchers want to find out if applying these medications can help lessen the redness and irritation that many people with rosacea experience when they are outdoors.

To participate in this study, individuals should be between the ages of 65 and 74 and have a specific skin type that is more sensitive to sunlight (Fitzpatrick Skin Type I to IIII). Participants must also have rosacea or no history of blushing if they are in the control group. Those who are currently using certain medications, have large tattoos in the testing areas, or have undergone specific treatments in the past three months may not be eligible. Participants can expect to apply the topical medications and be monitored for their effects on skin redness. This research could provide valuable insights into new treatments for managing rosacea.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Fitzpatrick Skin Type I - IIII
• • Self-identified rosacea or no history of flushing/blushing for controls
• • Able to provide medical history and list of medications -- control subjects will not be allowed to take medications that are known to be photosensitizers.
• Exclusion Criteria:
• • Using imipramine, amitriptyline or any other tricyclic antidepressant (oral or topical)
• • Using topical anti-inflammatory (within 1 week) or systemic agents (e.g. prednisone)
• • Large tattoos in the designated testing areas
• • Tanning bed use within last 3 months
• • Photodynamic Therapy or UCB treatments in past 3 months
• • Female Subjects: pregnant or nursing