Adipose Tissue and Symptomatic Gonarthrosis

Launched by CENTRE HOSPITALIER UNIVERSITAIRE DE NICE · Mar 13, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the relationship between adipose tissue (body fat) and symptomatic gonarthrosis, which is a type of arthritis affecting the knee. The researchers want to understand how obesity and inflammation related to body fat may influence the development and symptoms of knee osteoarthritis. The trial will focus on patients who are planning to undergo bariatric surgery, which is a weight loss surgery, and aims to see how weight loss may help relieve knee pain and improve overall joint health.

To be eligible for this trial, participants should be between 30 and 55 years old and have a high body mass index (BMI) of over 35, especially if they also have conditions like hypertension or diabetes. They should either have knee pain from gonarthrosis or have no signs of osteoarthritis. Participants will need to provide consent after receiving detailed information about the study. It’s important to note that certain individuals, such as those with recent knee injuries, specific medical conditions, or those who have been on certain diets, may not qualify for the study. Participants can expect to contribute to important research that could improve treatment approaches for knee osteoarthritis and obesity in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients aged between 30 and 55.
• • Patient with BMI \> 40 or Patient with BMI between 35-40 and presence of hypertension and/or diabetes and/or obstructive sleep apnea syndrome.
• • Patients scheduled for bypass or SLEEVE bariatric surgery.
• • Patients with symptomatic gonarthrosis or patients with no signs of osteoarthritis.
• • Patients who have given written consent following written and oral information.
• • Patient affiliated to a social security scheme.
• Exclusion Criteria:
• • Patient having undergone knee ligamentoplasty.
• • Patient with knee infiltration less than three months old.
• • In the group of patients with no osteoarthritis, no known osteoarthritis or signs of osteoarthritis in a joint other than the knee.
• • Patients treated with lipid-lowering or cholesterol-lowering drugs
• • Postmenopausal patients
• • Patient with weight change of more than 5% in the last 3 months
• • Patients with known systemic inflammatory or autoimmune diseases
• • Patients on special diets in the last 3 months (gluten-free, high-protein, low-carbohydrate diets)
• • Patient with knee pain of secondary origin: tumor, inflammation, infection, fracture
• • Patient with a contraindication to bariatric surgery
• • Patient protected by law under guardianship or curatorship, or unable to participate in a clinical study under article L. 1121-16 of the French Public Health Code.
• • Patient with insufficient command of the French language (assessed during interview).