Effects of Exogenous Ketone Ester Supplementation on 3-hydroxybutyrate Concentrations in Human Cerebrospinal Fluid

Launched by UNIVERSITY OF AARHUS · Mar 12, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how taking a special supplement called exogenous ketone ester affects the levels of a substance called 3-hydroxybutyrate (3-OHB) in both the blood and cerebrospinal fluid (the fluid surrounding the brain and spinal cord). Ketone bodies, like 3-OHB, can be used by the brain for energy, especially when sugar is low, such as during fasting. The researchers want to see how the timing of taking the supplement influences its effects, and whether simpler testing methods can measure 3-OHB as accurately as more complex laboratory techniques.

To participate in this study, you need to be between 18 and 80 years old, and you must be referred for a lumbar puncture (a procedure to collect cerebrospinal fluid) at Aarhus University Hospital. You should be able to understand and give consent in Danish, and you shouldn't be on a special diet like a ketogenic diet or using insulin regularly. If you join the trial, you will take the ketone supplement and then have your blood and cerebrospinal fluid tested to see how the supplement works in your body. This study is currently looking for participants, so if you meet the criteria, you could be part of this important research!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All sexes
• • Referred to undergo an elective lumbar puncture procedure in the outpatient clinic at Department of Neurology, Aarhus University Hospital.
• • Age 18-80 years
• • Written and oral consent
• Exclusion Criteria:
• • Referred to the clinic suspecting severe neuroinflammation
• • Special diet habits, including ketogenic diet, fasting, intermittent fasting etc.
• • Daily use of insulin or other medication affecting blood glucose and/or glucose metabolism
• • Not able to speak or understand Danish and/or give written and oral consent