TADCLOT- a Double Blind Randomized Controlled Trial

Launched by NATIONAL INSTITUTE OF CARDIOVASCULAR DISEASES, PAKISTAN · Mar 15, 2024

Keywords

ClinConnect Summary

The TADCLOT trial is a research study designed to find out which medication works better for patients who have had a heart attack and are undergoing a procedure called primary PCI (percutaneous coronary intervention). Specifically, it compares two medications: Clopidogrel, taken twice a day, and Ticagrelor. The goal is to see which of these treatments is safer and more effective in preventing serious health problems after the procedure.

To participate in this trial, you need to be at least 18 years old and have specific heart-related conditions that can be seen on an ECG (a test that checks the heart's rhythm). However, there are some important reasons you might not be able to join, such as recent bleeding problems, pregnancy, or serious kidney issues. If you decide to take part, you will receive either Clopidogrel or Ticagrelor, and neither you nor your doctor will know which one you are receiving until the study is over. This helps ensure that the results are fair and unbiased. Overall, this trial aims to improve treatment options for heart attack patients, and your participation could help advance medical knowledge in this area.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ST-segment elevation ≥1 mm in ≥ 2 contiguous ECG leads or New or presumably New left bundle branch block
• • Age ≥18 years
• • Written informed consent
• Exclusion Criteria:
• • Patients with STEMI secondary to stent thrombosis or index event being a complication of PCI within 30 days
• • Thrombolytic therapy \<24 hours
• • Platelet count \< 100,000 and Hemoglobin \<10 gm/dl
• • Pregnancy or lactation
• • Moderate to severe hepatic impairment
• • Patients with advanced CKD and those on hemodialysis
• • Recent ICH or major bleed requiring transfusion
• • Inability to give informed consent
• • Participation in another study
• • Inability to fulfill protocol (living outside the city etc.)