Effects of Aerobic Exercise in Obese Patients with Atherosclerotic Cardiovascular Disease

Launched by KAYSERI CITY HOSPITAL · Mar 13, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how aerobic exercise can help obese patients who also have a type of heart disease called atherosclerotic cardiovascular disease. Obesity is measured using a number called Body Mass Index (BMI), and this study will focus on patients who are classified as Class 1 or Class 2 obese (with a BMI between 30 and 39.9). The trial aims to see if regular aerobic exercise can improve health outcomes for these patients, especially since many may be afraid to exercise because of their heart condition.

To be eligible for the trial, participants must be between 18 and 65 years old, have a BMI of 30 or more, and have been diagnosed with atherosclerotic cardiovascular disease. Those with certain health issues, like severe asthma, uncontrolled diabetes, or other serious conditions, won't be able to participate. If you join the study, you can expect to take part in an exercise program designed to be safe for your heart while helping with weight management. This trial is not yet recruiting participants, but it represents an important step in understanding how exercise can benefit those struggling with obesity and heart disease.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Class 1 and class 2 obese patients with a BMI of 30 kg/m2 and above and below 40 kg/m2
• • 2. Patients with atherosclerotic cardiovascular disease diagnosed by angiography
• • 3. Women and men aged 18-65
• • 4. Individuals who agree to participate in the study and have received a written voluntary consent form.
• Exclusion Criteria:
• • 1. Clinical neuromuscular diseases that limit exercise, previous diagnosis of asthma, congestive heart failure, unstable angina, uncontrolled psychiatric disease or cognitive-cognitive disorders (confirmed and diagnosed in International Classification of Disease (ICD)-10 diagnosis codes 'Schizophrenia and Psychotic states (F20, F20.0, F20.1, F20.2, F20.3, F20.4, F20.5, F20.6, F20.8, F20.9, F06.2, F23.0, F23.1, F23.2, F29) , Bipolar Disorder (F31, F31.0, F31.1, F31.2, F31.3, F31.4, F31.5, F31.6, F31.7, F31.8, F31.9) and Substance Abuse (Patients with diagnosis code ' (Z86.4)')
• • 2. Presence of uncontrolled systemic diseases
• • Uncontrolled hypertension,
• • Uncontrolled diabetes mellitus,
• • Chronic liver failure
• • Chronic renal failure and dialysis patients
• • Chronic obstructive pulmonary disease and asthma
• • 3. Malignancy
• • 4. Infection
• • 5. High fever
• • 6. Acute inflammatory rheumatic diseases
• • 7. Acute peripheral vascular diseases
• • 8. Smoking before exercise test
• • 9. Alcohol consumption before exercise test
• • 10. Use of medications known to affect physical performance, heart rate or metabolism (including Beta blockers)
• • 11. Patients without cooperation and compliance
• • 12. Patients who did not agree to participate in the study
• • 13. Patients who have been included in the cardiopulmonary rehabilitation (CPR) program in the last year
• • 14. With acute coronary syndrome
• • 15. Troponin positive
• • 16. Unstable angina pectoris
• 17. Basic contraindications of exercise test:
• • High risk unstable angina
• • Acute Cardiac Diseases (Acute MI, Acute endocarditis, myocarditis or pericarditis, Acute pulmonary embolism, etc.)
• • Uncontrolled arrhythmias that can disrupt the hemodynamic response
• • Symptomatic severe aortic stenosis
• • Decompensated heart failure
• • Non-cardiac pathologies that will affect exercise performance and be aggravated by exercise (e.g. infection, renal failure, thyrotoxicosis).