Vascular Aspects in Dementia: Part 2

Launched by LEIDEN UNIVERSITY MEDICAL CENTER · Mar 18, 2024

Keywords

ClinConnect Summary

The clinical trial titled "Vascular Aspects in Dementia: Part 2" is studying a condition called cerebral amyloid angiopathy (CAA), which is often found in people with Alzheimer's disease (AD). The main goal of the study is to understand how blood flow changes in the brain during different stages of Alzheimer's and how this might relate to the worsening of memory and thinking skills. Researchers will use a special type of MRI scan to observe these blood flow changes and see how they progress over time in both individuals with early-stage Alzheimer's and healthy individuals.

To participate in this study, you may be eligible if you are between 50 and 90 years old and can give informed consent. This includes people who have been diagnosed with Alzheimer's, mild cognitive impairment (MCI), or are healthy adults without memory issues. Participants can expect to undergo MRI scans and share information about their memory and health. It’s important to note that certain conditions, like having a pacemaker or severe physical restrictions, may prevent someone from participating. This research is a crucial step in finding better treatments for Alzheimer's disease by understanding how CAA might influence its progression.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • For this study three different routes for inclusion exists. Inclusion criteria for each group separately are shown below.
• • 1. Participants who were included in our previous CASCADE study (P19.039).
• • Capable of giving informed consent (see appendix)
• • 2. Patients who attended a memory clinic within one year ago
• • Diagnosed with (mixed) probable AD
• • Diagnosed as MCI
• • Diagnosed as SCI
• • Age between 50-90 years
• • Capable of giving informed consent (see appendix)
• • 3. Control subjects
• • Healthy adults without memory complaints
• • Age between 50 -90 years
• • Capable of giving informed consent
• Exclusion Criteria:
• * Contra-indication to MRI scanning:
• • Claustrophobia
• • Pacemakers and defibrillators
• • Nerve stimulators
• • Intracranial clips
• • Intraorbital or intraocular metallic fragments
• • Cochlear implants
• • Ferromagnetic implants
• • Hydrocephaluspump
• • Intra-utrine device (not all types) Permanent make-up
• • Tattoos above the shoulders (not all)
• • Specific contraindications to fMRI
• • Seizure within prior year.
• • Noncorrectable visual impairment.
• • MMSE \< 19 points (measured at moment of screening or at memory clinic with a maximum of 6 months in retrospect)
• • Severe physical restrictions (completely wheelchair dependent)
• • Age above 90