The Role of Renal Progenitors and Polyploid Tubular Cell Response in Glomerular and Tubular Diseases

Launched by MEYER CHILDREN'S HOSPITAL IRCCS · Mar 15, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the role of special kidney cells called renal progenitors, which help repair damage in kidney diseases like nephropathy. Researchers are particularly interested in how these cells respond when kidney damage occurs, such as in conditions like acute kidney injury (AKI) and chronic kidney disease (CKD). By using advanced imaging techniques on kidney biopsies—tiny samples of kidney tissue—they hope to better understand how these cells can help regenerate and repair the kidneys.

To participate in this study, you may be eligible if you are between the ages of 30 and 6209 and have a kidney disease that requires a biopsy, such as diabetic nephropathy or lupus nephritis. If you have AKI from any cause, you may also qualify. Participants will need to sign an informed consent form, and the study will focus on gathering information that connects kidney cell behavior with the progression of kidney disease. This research aims to improve our understanding of kidney health and the potential for new treatments in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with glomerular diseases undergoing renal biopsy (e.g., rapidly progressive glomerulonephritis, minimal change disease, focal segmental glomerulosclerosis, diabetic nephropathy, lupus nephritis, membranous nephropathy, IgA nephropathy, etc)
• • Patients with AKI, regardless of the nature of the damage (septal, ischemic, toxic, or unknown).
• • Signed informed consent form
• Exclusion Criteria:
• • Sample insufficient and/or unavailable