Transcriptome Analysis in Idiopathic Nephrotic Syndrome: Steroid Responsiveness

Launched by IRCCS BURLO GAROFOLO · Mar 15, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a condition called idiopathic nephrotic syndrome (INS), which affects the kidneys and can lead to significant protein loss in urine. The researchers want to understand better how to identify patients who may not respond well to steroid treatments. By analyzing the genetic material (RNA) in blood samples from children with INS, they hope to find markers that can predict whether a patient will respond to steroids or not. This could help doctors avoid giving unnecessary steroid treatments to those who are unlikely to benefit from them.

To participate in this trial, children aged 1 to 12 years with a clinical diagnosis of INS may be eligible, provided their parents or guardians give consent. The study is currently recruiting participants and will focus on understanding their blood samples to look for specific genes linked to treatment response. Participants can expect to provide blood samples and undergo assessments that may contribute to future improvements in managing nephrotic syndrome. It's important to note that children with certain other kidney conditions or those over 12 years old will not be included in this study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • clinical diagnosis of INS
• • age 1 - 12 years
• • signed informed consent by parents or legal guardians
• • For controls: aged-matched individuals with Congenital Anomalies of the Kidney and Urinary Tract (CAKUT)
• Exclusion Criteria:
• • Patients aged \<1 year or \> 12 years
• • Patients diagnosed with a secondary or genetic form of NS
• • For controls: the presence of coexisting chronic kidney failure, autoimmune or autoinflammatory disease, or endocrinologic disorders.