Glycoxidation, Arterial Biomechanics, and Target Organ Damage

Launched by COMPLEJO HOSPITALARIO UNIVERSITARIO DE SANTIAGO · Mar 16, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how certain chemical changes in the body, known as glycation and glycoxidation, affect the health of our arteries and may lead to damage in important organs. Researchers want to learn more about these processes in people who seem healthy but have a moderate to high risk of heart-related issues. By examining various blood markers and using ultrasound to check the condition of arteries, the study aims to find connections between these chemical changes and the health of the cardiovascular system.

To participate, individuals must be at least 18 years old, not smoke currently or have smoked in the last six months, and not have diabetes or existing heart diseases. The study will involve regular monitoring and assessments, including blood tests and ultrasound exams, to track any changes over time. This research is important because it could help us understand better how to prevent cardiovascular problems in those at risk before they develop into more serious conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients aged 18 years or older.
• • Moderate to high Cardiovascular Risk estimated by SCORE2OP.
• • Signed written consent for participation in the study.
• Exclusion Criteria:
• • Absence of current smoking habit and in the last 6 months.
• • High-risk alcohol consumption (More than 10 and 20 g/day in women and men, respectively).
• • Presence of Diabetes mellitus.
• • Established cardiovascular disease, including heart failure, ischemic heart disease, valvular heart disease, atrial fibrillation, peripheral artery disease, and cerebrovascular disease.