Treatment Of Oral Lichen Planus

Launched by MANSOURA UNIVERSITY · Mar 18, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment for oral lichen planus (OLP), a condition that causes painful sores in the mouth and can be hard to treat. The researchers want to see if Daivobet ointment, which contains a type of vitamin D and a steroid, can help relieve the symptoms of OLP. The trial will involve 15 adults aged 30 to 60 who have been diagnosed with erosive oral lichen planus and have not found relief from other treatments. Participants will apply the ointment three times a day for four weeks and will be monitored for changes in their condition.

To be eligible for the study, participants must have specific signs of oral lichen planus confirmed by a biopsy and must not have recently used other medications for this condition. Throughout the trial, researchers will assess how well the treatment works by evaluating the sores in the mouth and asking participants about any discomfort they experience. This trial aims to provide new insights into a potential alternative treatment for those suffering from this challenging condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age between 30-60 years. Clinical signs and symptoms of bilateral intra-oral erosive lichen planus. History of unresponsiveness to currently available therapy. Histopathological confirmation by incisional biopsy. Willingness to topically apply Daivobet ointment in one side and topical steroid in the other side three times daily for 4 weeks.
• Exclusion Criteria:
• • Histological signs of dysplasia. Use of drugs possibly causing a lichenoid reaction. Lesions in contact with dental amalgam restorations. Any topical or systemic medications used in the treatment of oral lichen planus within four weeks before the study.
• • History of hypersensitivity to the drug used in the current study.