The Influence of Nutritional Factors on the Prognosis of Liver Cirrhosis Patients and the Exploration of Predictive Models

Launched by JUAN KANG · Mar 19, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how nutrition affects the health and survival of patients with cirrhosis, which is a serious liver condition. The researchers want to create a special tool, called a nomogram, that can predict how well patients with cirrhosis will do based on their nutritional status. They believe that by focusing on nutrition, they can help improve the overall health and outcomes for these patients, especially since malnutrition is a common problem in people with cirrhosis and can lead to more complications.

To participate in this study, individuals must be between the ages of 18 and 75, have a diagnosis of cirrhosis confirmed through imaging tests, and be expected to live for at least three more months. They also need to be able to understand and sign a consent form. However, those with certain conditions, like liver cancer, severe heart or lung diseases, or who are pregnant, may not be eligible. Participants in the study will help researchers learn more about the important role of nutrition in cirrhosis, aiming for better treatment options in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Willing and able to sign an informed consent form;
• • 2. Abdominal ultrasound, CT, or MRI showed cirrhosis during the screening period; Fibroscan results during the screening period were\> 17.5kPa;
• • 3. Estimated survival time of more than 3 months;
• • 4. Full capacity for civil conduct.
• Exclusion Criteria:
• • 1. The diagnosis of primary liver cancer or was supported by the following evidence: increased alpha-fetoprotein (AFP) (≥100 μg/L) for more than 3 months or liver imaging showed clear liver cancer nodules in the liver;
• • 2. A history of malignancy within 5 years prior to screening, except for specific cancers (such as basal cell skin cancer); current or prior history of major disease that may interfere with personal treatment, assessment or compliance. Major diseases are 25 major diseases as stipulated by the China Insurance Regulatory Commission;
• • 3. Severe lung disease, severe heart disease, diabetes mellitus, or genetic and metabolic diseases;
• • 4. Psychiatric hospitalization, attempted suicide, and / or temporary disability due to mental illness in the past five years;
• • 5. Pregnant or lactating women;
• • 6. The investigator considered not unsuitable for participants.