The Effects of Losartan on Attention Control: An Eye-tracking Study

Launched by UNIVERSITY OF ELECTRONIC SCIENCE AND TECHNOLOGY OF CHINA · Mar 15, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how a medication called Losartan affects attention control, particularly when looking at social and emotional cues. Researchers want to see if Losartan can help improve how we pay attention to important information in our environment. The study will use eye-tracking technology, which means they will be watching how your eyes move while you respond to different tasks. Some participants will receive Losartan, while others will receive a placebo, which is a pill that looks like the medication but doesn’t have any active ingredients.

To join this study, participants must be healthy adults between the ages of 65 and 74 who can understand and agree to the study terms. People with certain medical conditions, such as heart or liver diseases, or those who take specific medications, will not be eligible. If you decide to participate, you can expect to take the medication for a short time and complete various tasks while your eye movements are recorded. It's a great opportunity to contribute to research that could help improve our understanding of attention and how medications can affect it.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy subjects who volunteer to participate and are able to fully understand and agree with this study by written informed consent.
• • Normal or corrected-normal version
• Exclusion Criteria:
• • History of neuropsychiatric diseases.
• • History of cardiac disease, including arrhythmias, aortic stenosis, or congestive heart failure; history of syncope or unexplained loss of consciousness.
• • History of hepatic diseases, including cholestasis, biliary obstructive disease, or severe liver dysfunction.
• • History of renal diseases, including renal stones or renal failure.
• • History of hyponatremia(Serum sodium \<135mmol/L) or hyperkalemia (Serum potassium\>5.5mmol/L); history of diabetes mellitus or diabetes insipidus
• • Known hypersensitivity or allergic reaction to any medication or hormone; strong allergic reaction to food.
• • Infections such as COVID-19 or influenza, or unexplained fever.
• • Subjects with hypertension (BP ≥130/80mmHg) or hypotension (BP ≤ 90/60mmHg).
• • History of alcohol or drug abuse; smoker (≥ 10 cigarettes or ≥ 3 cigars or ≥ 3 pipes/day); smoker using e-cigarettes.
• • Blood donation (≤ 1 month prior to administration).
• • Take oral contraceptives or receive hormonal medications in the three months prior to the experiment.
• • Pregnant or breastfeeding.