Oral Vasopressin Modulates Neural Responses to Looming Visual Stimuli: An Eye-tracking Study

Launched by UNIVERSITY OF ELECTRONIC SCIENCE AND TECHNOLOGY OF CHINA · Mar 15, 2024

Keywords

ClinConnect Summary

This clinical trial is exploring how a hormone called vasopressin, taken by mouth, affects how people perceive time when objects are approaching them, which can be important for understanding how we respond to potential threats. The study will involve healthy volunteers who will be given either the vasopressin or a placebo (a pill with no active medication) to see how it changes their reactions to visual stimuli.

To participate, you need to be a healthy adult aged between 65 to 74 years old, and you must be able to understand the study and provide written consent. However, if you have a history of certain health issues, such as heart problems, liver or kidney diseases, or significant allergies, you may not be eligible. Participants will likely engage in eye-tracking activities to measure their responses, and the study is currently looking for volunteers to help with this important research.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy subjects who volunteer to participate and are able to fully understand and agree with this study by written informed consent.
• • Normal or corrected-normal version
• Exclusion Criteria:
• • History of neuropsychiatric diseases.
• • History of cardiac disease, including arrhythmias, aortic stenosis, or congestive heart failure; history of syncope or unexplained loss of consciousness.
• • History of hepatic diseases, including cholestasis, biliary obstructive disease, or severe liver dysfunction.
• • History of renal diseases, including renal stones or renal failure.
• • History of hyponatremia(Serum sodium \<135mmol/L) or hyperkalemia (Serum potassium\>5.5mmol/L); history of diabetes mellitus or diabetes insipidus
• • Known hypersensitivity or allergic reaction to any medication or hormone; strong allergic reaction to food.
• • Infections such as COVID-19 or influenza, or unexplained fever.
• • Subjects with hypertension (BP ≥130/80mmHg) or hypotension (BP ≤ 90/60mmHg).
• • History of alcohol or drug abuse; smoker (≥ 10 cigarettes or ≥ 3 cigars or ≥ 3 pipes/day); smoker using e-cigarettes.