Losartan Modulates Neural Responses to Looming Visual Stimuli: An Eye-tracking Study

Launched by UNIVERSITY OF ELECTRONIC SCIENCE AND TECHNOLOGY OF CHINA · Mar 15, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a medication called losartan to see how it affects how people perceive danger when they see something approaching quickly, like a car or a ball. Researchers want to understand if losartan, which is usually used to treat high blood pressure, can change how our eyes and brains react to these "looming" visual cues. The study involves healthy volunteers, which means that participants should not have any serious medical conditions or a history of certain diseases.

To participate, you need to be a healthy adult aged 18 to 75 who can understand and agree to the study by signing a consent form. Participants should have normal vision or wear glasses or contacts to correct their vision. If you have any serious health issues, particularly related to the heart, liver, or kidneys, or if you have high or low blood pressure, you may not be eligible. If you join the study, you will receive either losartan or a placebo (a pill with no active medication) and take part in eye-tracking tests to see how you respond to different visual stimuli. This research could help scientists learn more about how our brains process threats.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy subjects who volunteer to participate and are able to fully understand and agree with this study by written informed consent.
• • Normal or corrected-normal version
• Exclusion Criteria:
• • History of neuropsychiatric diseases.
• • History of cardiac disease, including arrhythmias, aortic stenosis, or congestive heart failure; history of syncope or unexplained loss of consciousness.
• • History of hepatic diseases, including cholestasis, biliary obstructive disease, or severe liver dysfunction.
• • History of renal diseases, including renal stones or renal failure.
• • History of hyponatremia(Serum sodium \<135mmol/L) or hyperkalemia (Serum potassium\>5.5mmol/L); history of diabetes mellitus or diabetes insipidus
• • Known hypersensitivity or allergic reaction to any medication or hormone; strong allergic reaction to food.
• • Infections such as COVID-19 or influenza, or unexplained fever.
• • Subjects with hypertension (BP ≥130/80mmHg) or hypotension (BP ≤ 90/60mmHg).
• • History of alcohol or drug abuse; smoker (≥ 10 cigarettes or ≥ 3 cigars or ≥ 3 pipes/day); smoker using e-cigarettes.
• • Blood donation (≤ 1 month prior to administration).
• • Take oral contraceptives or receive hormonal medications in the three months prior to the experiment.