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Search / Trial NCT06329349

Metabolic Flexibility to Predict Lifestyle Interventions Outcomes

Launched by CHARLES UNIVERSITY, CZECH REPUBLIC · Mar 22, 2024

Trial Information

Current as of August 20, 2025

Recruiting

Keywords

Obesity Metabolic Flexibility Metabolomic Exercise Diet

ClinConnect Summary

This clinical trial, called MEPHISTO, is studying how our bodies respond to exercise and diet changes in people living with obesity. The goal is to find out what specific factors help some individuals lose weight more successfully than others. By examining both the body’s overall metabolism and the gut microbiome (the bacteria in our digestive system), researchers hope to identify patterns that can predict who will benefit the most from lifestyle changes aimed at weight loss.

To participate in this study, women aged 25 to 45 with a body mass index (BMI) over 30 may be eligible. However, those with active cancer, diabetes, certain uncontrolled health conditions, or who are pregnant or breastfeeding cannot take part. If you join the trial, you can expect to undergo various tests to measure your metabolism before and after following an exercise and diet program. This research could lead to more personalized and effective weight loss strategies for individuals with obesity in the future.

Gender

FEMALE

Eligibility criteria

  • Inclusion Criteria:
  • BMI\>30
  • age 25-45 years
  • Exclusion Criteria:
  • active cancer
  • diabetes (medical history, fasting glycemia \>7.6 and/or 2hOGTT glycemia \>11.1)
  • uncontrolled endocrine diseases
  • corticosteroid therapy
  • immune-suppressive therapy
  • pregnancy
  • breastfeeding

About Charles University, Czech Republic

Charles University, located in the Czech Republic, is a prestigious institution renowned for its commitment to advancing medical research and education. As a clinical trial sponsor, the university leverages its extensive academic expertise and state-of-the-art facilities to conduct innovative research that aims to improve patient outcomes and contribute to the global medical community. With a focus on ethical standards and rigorous scientific methodologies, Charles University collaborates with various stakeholders to explore new therapies and enhance healthcare practices, fostering a culture of excellence in clinical research.

Locations

Prague, , Czechia

Prague, , Czechia

Prague, , Czechia

Patients applied

0 patients applied

Trial Officials

Jan Gojda

Principal Investigator

Third Faculty of Medicine Charles University

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported