High Fructose Diet, the Gut Microbiome, and Metabolic Health

Launched by ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · Mar 18, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating how a high fructose diet affects our gut health and its connection to metabolic conditions like type 2 diabetes and obesity. Researchers want to understand if eating too much fructose, which is commonly found in sugary foods and drinks, can change the bacteria in our gut and increase the risk of developing metabolic health issues. They will do this by having 30 participants follow two different diets for 12 days each—one high in fructose and the other high in glucose, with a break in between. Participants will be monitored for changes in their gut bacteria, metabolism, and other health markers.

To be eligible, participants need to have difficulty absorbing fructose, which will be determined through a simple breath test. They should not be taking certain supplements, consuming more than one sugary drink per day, or have any major health issues like diabetes. Throughout the study, participants can expect to eat a controlled diet and provide stool samples for analysis. The findings from this research could help identify new ways to improve metabolic health, especially for those who consume a lot of fructose, such as children.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participants must be determined to be a fructose malabsorber (screening visit) via hydrogen breath test.
• Exclusion Criteria:
• • Use of probiotic/prebiotic/synbiotic supplements
• • Consumption of \> 1 sugar sweetened beverage per day
• • Antibiotics within 3 months prior to enrollment or during intervention
• • Vegetarian, vegan or other restrictive dietary habits
• • Food allergy
• • Alcohol consumption in excess of 2 drink per day
• The following additional factors will be exclusion criteria:
• • Physician diagnosis of a major medical illness (including type 1 or type 2 diabetes) or eating disorder
• • Physical, mental, or cognitive handicaps that prevent participation
• • Chronic use of any medication that may affect body weight or composition, insulin resistance, or lipid profiles;
• • Current smoking (more than 1 cigarette in the past week) or use of other recreational drugs; e) restrictive dietary habits;
• • food allergy;
• • excess alcohol consumption;
• • recent use of pro-, pre- or Synbiotics of receipt of antibiotics within 3 months prior to enrollment or during the intervention;
• • consumption of greater than 1 sugar sweetened beverage per day prior to enrollment