Inpatient Monitoring of Unfractionated Heparin

Launched by VANDERBILT UNIVERSITY MEDICAL CENTER · Mar 19, 2024

Keywords

ClinConnect Summary

Unfractionated heparin (UFH) is the most widely used intravenous (IV) anticoagulant for the treatment and prevention of thromboembolic disease (e.g., blood clots ). When administered by intravenous injection, the onset of action is immediate. Indications for use of UFH include venous thromboembolism, acute coronary syndrome, and acute ischemic stroke. UFH is used to prevent thrombosis in the setting of arrhythmias, extracorporeal membrane oxygenation (ECMO), cardiopulmonary bypass (CPB), and endovascular procedures. The unpredictable pharmacokinetics of UFH and interpatient variability resu...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients at Vanderbilt University Hospital age 18 years and older who are admitted as observation or inpatients for whom intravenous unfractionated heparin (monitored via the PTT nurse-managed protocol) is ordered.
• • Baseline PTT value is ≥0 and ≤ 36.0 seconds
• • Baseline heparin level anti-Xa assay value is ≥0 and ≤0.3
• Exclusion Criteria:
• • Indication for anticoagulation is extracorporeal membrane oxygenation or cerebrovascular ischemic event.
• • Provider determines patient is not appropriate for the study.