Radiation Therapy for Dupuytren's Contracture Following Non-Surgical Release

Launched by DARTMOUTH-HITCHCOCK MEDICAL CENTER · Mar 19, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how targeted radiation therapy can help prevent Dupuytren's Contracture from coming back after non-surgical treatment with an injection called Collagenase Clostridium Histolyticum (CCH). Dupuytren's Contracture is a condition that causes the fingers to bend towards the palm, making it difficult to fully extend them. The trial will involve participants who are 45 years or older, have a noticeable bending of their fingers, and cannot lay their hand flat on a table.

Participants in the trial will first receive the CCH injection to release the contracture, followed by five days of daily radiation therapy. After a break of 6 to 8 weeks, they will receive another five days of radiation therapy. The study is currently looking for participants, and it's important to note that those with certain health issues or who are pregnant cannot take part. This trial aims to provide valuable information on whether radiation therapy can reduce the chances of Dupuytren's Contracture returning after treatment.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 45 or greater with DC
• • Extension deficit \>10 degrees
• • Unable to simultaneously place the affected finger and palm flat on a table.
• • Women included in the study will be post-menopausal or using contraception, and a pregnancy test will be performed as standard of care.
• • For patients who are having multiple CCH injections, only the first 2 joints on given hand will be included
• Exclusion Criteria:
• • Unsuccessful non-surgical release (\> N/1 disease)
• • They develop an open wound during CCH
• • Breast feeding or pregnancy
• • A chronic muscular, neurologic, or neuromuscular disorder affecting the hands.
• • Less than the age of 45
• • They have previously undergone radiation on the hand in which they plan to get CCH injections
• • They are pregnant women, impaired adults or prisoners