MIND Diet to Improve Cognitive Function in Mild Stroke Patients (MINDICOMS) II

Launched by ZHEJIANG UNIVERSITY · Mar 20, 2024

Keywords

ClinConnect Summary

The MIND Diet to Improve Cognitive Function in Mild Stroke Patients (MINDICOMS) II trial is studying whether following a specific healthy eating plan called the MIND Diet can help improve thinking and memory in people who have had a mild stroke. This diet combines elements of the Mediterranean diet and the DASH diet, focusing on foods that may support brain health. The study involves 60 participants aged 35 to 70 who are recovering from a recent mild stroke and shows signs of cognitive decline, but who do not have dementia.

To join the trial, participants must have had a mild stroke within the last two weeks and have certain scores indicating mild cognitive issues. They should be able to eat solid foods and not have any serious medical conditions, like cancer or severe liver disease. Over the 6-month study period, participants will follow the MIND Diet while continuing their usual medical care. They will be asked to avoid certain over-the-counter supplements during the trial. This study aims to see if this diet can positively impact their cognitive health, making it a potentially valuable option for improving recovery after a stroke.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Clinically confirmed new cerebral infarction, onset hospitalization time ≤14 days
• • National Institutes of Health Stroke Scale (NIHSS) score of 0-6, with no difficulty in autonomous eating or aphasia
• • Baseline MMSE score being 16-25/30 points or MoCA score ≤24/30 points, with signs of post-stroke cognitive decline
• • Baseline MIND dietary pattern screening scale score ≤10/15 points
• • Body mass index no less than 18.0 kg/m2
• • Normal chewing function, able to eat hard foods such as nuts
• • Willing to participate and sign an informed consent form
• • Agree not to take over-the-counter nutritional supplements during the trial period
• • Able to understand research procedures and adhere to them throughout the entire study period
• • Completed the run-in test
• Exclusion Criteria:
• • Diagnosis of dementia at a county-level or above hospital before the stroke or suspected to have pre-stroke dementia from the informant interview administered by a neurologist.
• • Participation in or have participated in other clinical trial studies within the past year
• • Allergies to foods involved in the experiment (nuts, berries, olive oil, or fish, etc.) or using drugs not compatible with foods involved.
• • Medication to treat Alzheimer's or Parkinson's disease
• • Diagnosis of cancer, severe liver and kidney disease, or current life expectancy less than 6 months
• • Diagnosis of depression, bipolar disorder, or other mental illnesses
• • Pregnancy or breastfeeding or with a pregnancy plan
• • Diagnosis of inflammatory bowel disease or other malabsorption-related gastrointestinal diseases
• • History of alcohol or drug abuse