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Search / Trial NCT06331442

The Effect of Photodynamic Therapy on Plaque in Orthodontic Patients

Launched by UNIVERSITY OF ZAGREB · Mar 19, 2024

Trial Information

Current as of July 25, 2025

Not yet recruiting

Keywords

Dental Plaque Gingiva White Spot Lesion Photodynamic Therapy Chlorhexidine Varnish Tricalcium Phosphate Varnish Fluoride

ClinConnect Summary

This clinical trial is studying the effects of different treatments on plaque buildup in young patients who are undergoing orthodontic treatment, like braces. Specifically, researchers want to see how well photodynamic therapy, a special light treatment, works compared to other options like a fluoride varnish and a chlorhexidine varnish. The trial will involve 40 participants aged 12 to 17 years who need braces but don’t have any serious dental issues. Throughout the study, researchers will measure the amount of plaque and assess gum health before and after the treatments.

To participate, patients must be between 12 and 17 years old, have permanent teeth, and be ready for fixed braces, but they should not have had any previous orthodontic treatment or certain health conditions that could affect their oral health. Participants can expect to have their plaque levels and gum conditions checked at the start and end of the trial. This study is not yet recruiting participants, but it aims to find effective ways to help manage plaque and improve oral health in young orthodontic patients.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • 12 to 17 years of age
  • indication for fixed orthodontic treatment without the need for extraction
  • permanent dentition (including second molars)
  • absence of oral lesions, caries, pulpal and periapical diseases and gingival and periodontal diseases
  • Exclusion Criteria:
  • previous orthodontic treatment
  • taking antibiotics and anti-inflammatory drugs 3 months before the study and during the study
  • use of antiseptic rinses 3 months before the study and during the study
  • taking corticosteroids and immunosuppressive drugs
  • smoking
  • systemic conditions that can affect the inflammatory response of soft tissues and the possibility of maintaining adequate plaque control (diabetes, immune disorders, etc.)

About University Of Zagreb

The University of Zagreb, a leading academic institution in Croatia, is committed to advancing medical research and improving healthcare outcomes through innovative clinical trials. With a focus on interdisciplinary collaboration, the university harnesses its extensive expertise and state-of-the-art facilities to conduct rigorous clinical studies that address pressing health challenges. By fostering partnerships with healthcare professionals, industry leaders, and regulatory bodies, the University of Zagreb aims to translate scientific discoveries into practical applications, ultimately enhancing patient care and contributing to the global body of medical knowledge.

Locations

Patients applied

0 patients applied

Trial Officials

Tadeja Blagec, DMD

Principal Investigator

University of Zagreb School of Dental Medicine

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported