Postoperative Quality of Recovery After General Anesthesia With Remimazolam

Launched by BEIJING CHAO YANG HOSPITAL · Mar 25, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how well patients recover after surgery when two different types of anesthesia are used. Specifically, it compares a newer medication called remimazolam with a more commonly used drug called propofol. The trial will involve 126 patients who are having elective surgeries at Beijing Chaoyang Hospital. The main goal is to see how the quality of recovery differs between patients given remimazolam and those given propofol, with patients being assessed 24 hours after their surgery.

To participate in this trial, candidates must be between 18 and 65 years old, have a scheduled surgery that lasts less than three hours, and have a low to moderate risk of health issues (classified as ASA I-II). However, certain individuals, such as pregnant women or those with serious health problems affecting the lungs, heart, liver, or kidneys, cannot participate. If eligible, participants can expect to receive anesthesia through an intravenous (IV) line and will be closely monitored during and after their surgery to ensure their safety and comfort.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. ASA was classified as I-II
• • 2. The operative time was less than 180 minutes
• • 3. Age ranges from 18 to 65 years
• • 4. Informed consent is signed by all study participants
• Exclusion Criteria:
• • 1. Pregnant or lactating women
• • 2. Patients with Difficult Airways
• • 3. History of severe neurological and muscular diseases and mental retardation
• • 4. Patients with severe respiratory and circulatory diseases
• • 5. Abnormal liver and kidney function: ALT and/or AST exceeding 2.5 times the upper limit of the medical reference range
• • 6. Urea or urea nitrogen ≥1.5×ULN, serum creatinine greater than the upper limit of normal
• • 7. Take diazole drugs and/or opioids in one month or nearly three months
• • 8. Patients who were allergic to or contraindicated to benzodiazepines, opioids, propofol, flumazenil, naloxone, etc
• • 9. Patients who could not monitor the depth of anesthesia for various reasons