Metabolic Availability in Older and Younger Men

Launched by WAGENINGEN UNIVERSITY · Mar 19, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating how well the body can use certain nutrients—specifically methionine from black beans, lysine from sorghum, and lysine from milk—in older and younger men. The researchers want to understand if age affects how these nutrients are absorbed and utilized in the body. The study is currently looking for male participants aged between 20-35 years or 65-80 years who are generally healthy and have normal eating habits.

To be eligible for the study, participants need to have a Body Mass Index (BMI) between 18.5 and 30.0 and should not have any chronic diseases like diabetes or cancer. They must also be willing to follow the study guidelines and provide consent. Participants will undergo assessments to measure how their bodies metabolize these nutrients, contributing to our understanding of nutrition in relation to aging. It’s important to note that individuals with certain health issues or those on specific medications may not qualify for this study.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Gender: Male Age: 20-35 years or 65-80 years Body Mass Index (BMI): 18.5 - 30.0 kg/m2 Healthy as assessed with a questionnaire Regular and normal eating habits as assessed with a Food Frequency Questionnaire (FFQ) Willing to comply with study procedures and use of data Having given written informed consent
• Exclusion Criteria:
• Chronic disease, for example:
• • Diabetes mellitus / being treated for high blood glucose
• • Severe cardiovascular disease (exception: hypertension)
• • Hepatic disease (e.g. hepatitis)
• • Renal disease
• • Cancer
• • Bowel disease (e.g. inflammatory bowel disease, ulcers, bleeding)
• • Pancreatitis
• History of medical or surgical events that may affect GI function, and the study outcomes or disease risk for participants, for example:
• • Bariatric surgery
• • Gastrointestinal tract surgery
• • Digestive tract disorder
• • Chewing problems
• • History of deep venous thrombosis without anti-coagulation medication
• Medicine use that interferes with, protein metabolism, GI function and the study outcomes, for example:
• • Glucose lowering drugs
• • Proton pump inhibitors
• • Laxatives
• Habits that interfere with the study outcomes:
• • Protein supplement use (current use or less than 2 weeks past use)
• • Smoking
• • Drug use
• • Alcohol consumption \>21 units/week and/or \>4/day
• • Following a weight-loss diet, medically prescribed diet or other diet with a low calorie intake or an unbalanced nutrient intake like a vegan or very low carbohydrate diet
• • Moderate to high intense physical activity for more than 5 hours a week
• Other:
• • Self-reported allergy or intolerance to the tested products
• • Weight loss of more than 3 kg in the 3 months prior to study screening
• • Current participation in other research and \<2 months prior participation in other research
• • Not having a general practitioner
• • Not willing to accept information-transfer concerning participation in the study , or information regarding his health to his general practitioner
• • Working or doing an MSc- thesis at the department of Human Nutrition and Health at Wageningen University \& Research