Deciphering the Role of Incretin Hormones in Weight Loss-induced Remission of Type 2 Diabetes (DIABeat)

Launched by AZIENDA OSPEDALIERO, UNIVERSITARIA PISANA · Mar 20, 2024

Keywords

ClinConnect Summary

The DIABeat clinical trial is designed to explore how certain hormones in our body, called incretin hormones, can help people with type 2 diabetes achieve remission after losing weight. Essentially, the researchers want to understand how weight loss affects these hormones and how that might lead to improvements in blood sugar levels for those with diabetes. This study is important because it could help develop better treatments for managing type 2 diabetes, especially for those who are also dealing with obesity.

To participate in this trial, you need to be between 18 and 65 years old, have type 2 diabetes for less than six years, and have a body mass index (BMI) between 27 and 45, which indicates obesity. However, there are some factors that would exclude you from participating, such as having type 1 diabetes, being treated with certain medications, or having serious health issues like severe heart failure or recent heart attacks. If you join the study, you'll have the chance to contribute to important research that could lead to new ways to help people manage their diabetes through weight loss. This trial is not yet recruiting participants, so it’s a good idea to keep an eye out for when it starts!

Gender

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Eligibility criteria

• Inclusion Criteria:
• • T2D for less than 6 years;
• • age 18-65 years;
• • both genders;
• • BMI 27-45 kg/m2;
• • HbA1c 48-108 mmol/mol (43-108 mmol/mol if on glucose-lowering drugs).
• Exclusion Criteria:
• • type 1 or secondary/genetic diabetes;
• • treatment with insulin, Glucagon-Like Peptide-1 agonists, Gastric Inhibitory Peptide/GLP-1 co-agonists, or pioglitazone;
• • weight loss \>5% within the previous 6 months;
• • eGFR \<30 ml/min/1.73m2;
• • myocardial infarction within the previous 6 months;
• • severe heart failure (NYHA III-IV); eating disorder; substance abuse;
• • severe depression;
• • known cancer;
• • pregnancy.